Utilizing AI for predictive modeling of SAR & perform rational design enhancing the development of effective RNA therapeutics.
Leveraging AI Expertise for RNA Therapeutics
Our role as a leader in artificial intelligence applications extends to providing expert consultancy in the development of RNA therapeutics. We harness sophisticated AI technologies to empower our clients in the biomedical sector, helping them advance their drug discovery processes with precision and innovation. Our comprehensive expertise focuses on key areas such as UTR design, IRES engineering, structure-based search methods, codon optimization, and RNA:RBP binding, each critical to enhancing RNA-based therapeutic strategies.
UTR/IRES Design Using Language Models
Our consultancy employs advanced language models to guide clients in optimizing untranslated regions (UTRs) of mRNA or circRNA. These AI-driven models analyze extensive gene expression datasets to predict effective UTR configurations that improve mRNA stability and translational efficiency, tailored for specific therapeutic targets. By advising on UTR design, we enable more precise control over protein expression and stability, crucial for successful therapeutic outcomes.
Structure-Based Search Methods
Our structure-based search methods leverage AI to predict and design the three-dimensional structure of RNA molecules. This capability is instrumental in developing RNA therapeutics with precise functions and high specificity. We guide our clients through the complex landscape of RNA folding and interaction, enabling the identification of optimal structures that achieve targeted therapeutic actions.
Codon Optimization
Through codon optimization, we assist clients in enhancing protein expression from therapeutic genes. Our approches analyze host organism preferences to tailor RNA sequences for optimal codon usage, maximizing protein synthesis and therapeutic efficacy. This tailored approach is vital for ensuring that RNA therapies perform optimally in specific biological contexts.
RNA:RBP Binding Enhancement
We also specialize in enhancing RNA interactions with RNA-binding proteins (RBPs), which play a critical role in the stability and function of RNA within cells. Our AI-driven predictions and designs improve RNA:RBP interactions, thereby enhancing the therapeutic RNA’s stability, localization, and efficiency. This consultancy service is key to developing RNA therapeutics that are both effective and durable in clinical settings.
Our Commitment
We empower our clients with the knowledge and tools necessary to innovate and excel in the field of RNA therapeutics. Our commitment lies in providing top-tier AI and computational biology expertise, guiding drug developers through the intricacies of RNA therapy design and optimization. By partnering with us, our clients gain access to leading-edge technologies and insights that drive the future of medicine and therapeutic development.
